VHL and adrenal gland pheochromocytoma: After performing a series of experiments utilizing wild-type VHL30 and VHL30 carrying selected missense genetic changes, the researchers concluded that altered microtubule stabilization due to the investigated missense genetic changes, p.Y98H and p.Y112H, contributed predominantly to the development of VHL hemangioblastoma and PCC (classified as type 2A VHL disease), whereas p.F119S-induced destabilization of microtubules was characteristic of the type 2C PCC phenotype [98].