PBRM1, or protein polybromo-1, which is a subunit of ATP-dependent chromatin-remodeling complexes, and SET2D, a histone methyltransferase that specifically trimethylates lysine 36 of histone H3 (H3K36me3), were among the top mutated genes in RCC. Here, PBRM1 is linked to renal cell carcinoma.