IGF1R and cancer: The comparisons M81 vs. Ctrl and M81 vs. B95.8 also were predicted to regulate pathways involved in chromatin organization, extracellular matrix organization, program cell death, vesicle-mediated transport, metabolism of proteins, gene transcription, immune system regulation, and important pathways in cancer, such as MAPK, TGF-β, WNT, VEGF, and IGF1R (Figure 3D, Figure 4E–G and Figure 5).