BRCA2 and breast carcinoma: Moreover, it was previously reported in male breast cancer patients [39,40], suggesting high penetrance in PDAC and MBC development in carriers of DM c.631G>A (p.Val211Ile)/c.7008-2A>T (IVS13-2A>T).Remarkably, in the present study, we describe a novel germline mutation in BRCA2 gene, c.5511delT (p.Phe1837LeufsX3), previously observed in tissue of mucoepidermoid carcinoma [23].