The American College of Gastroenterology recommends screening for individuals with mutationsin STK11 or CDKN2A genes; with a mutation in BRCA1/2, ATM, PALB2, or MMR and a first- or second-degree relative with PDAC; with Peutz–Jeghers syndrome; and in families with at two cases of PDAC, with a first degree relative with pancreatic cancer [53]. This evidence concerns the gene ATM and familial pancreatic carcinoma.