Our findings showed that a high incidence of PDAC, which results in the second most recurrent tumor in HBOC and FAP families and the third in LS families, with an earlier onset and a reduced survival, could be notable in all patients with PDAC diagnosis, not only BRCA mutational screening, but also of other genes involved in cancer syndromes understanding PDAC. The gene discussed is FAP; the disease is neoplasm.