Indeed, the decreased expression of respiratory chain complexes (CI, CIII, and CV) and the consequent impairment of the ability to synthesize ATP may give rise to several vicious cycles involving ROS, the respiratory chain polypeptides themselves, and mtDNA, which together with putative-increased lipogenesis and decreased fatty acid β-oxidation lead to fat-engorged liver and insulin resistance. Here, NDUFB6 is linked to Insulin resistance.