No association between AP occurrence and tobacco smoke-exposure in the subjects with GC (OR = 0.8746, p = 0.9979), GG (OR = 0.7989, p = 0.8545), and CC genotypes (OR = 1.0000, reference) for SNPs 1800795 in the IL6 gene was observed. This evidence concerns the gene IL6 and alkaline phosphatase measurement.