One of the largest cervical cancer sequencing efforts—The Cancer Genome Atlas (TCGA) Project—reveals novel mutations in several genes, including SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2, amplifications in immune targets PD-L1 and PD-L2, by sequencing 228 primary cervical cancer patients. The gene discussed is PDCD1LG2; the disease is cervical cancer.