PAX8 and cervical carcinoma: Kyrgiou et al., undertook a genome-wide association study (GWAS) of 273,377 women, including 4769 cervical intraepithelial neoplasia (CIN) grade 3 or invasive cervical cancer patients, and showed that six independent genetic susceptibility variants, PAX8 (rs10175462), CLPTM1L (rs27069), HLA-DQA1 (rs9272050), MICA (rs6938453), HLA-DQB1 (rs55986091) and HLA-B (rs92666183), were associated with CIN3 and invasive cervical cancer, suggesting disruptions in apoptotic and immune function pathways [5].