To better understand the prevalence of the mutations in BRCA1 and BRCA2 genes among those with HBOC syndrome, this study was conducted to screen entire BRCA1 and BRCA2 genes for breast and ovarian cancer patients with a family history of breast cancer and ovarian cancer, thereby suggesting a risk score associated with carrier status and history for aiding personalized treatment. This evidence concerns the gene BRCA2 and breast carcinoma.