MAP3K3 and juvenile Huntington disease: Most proteins belong to the integrin signaling pathway (13.3%), inflammation mediated by chemokine and cytokine signaling pathway (6.7%), Huntington’s disease (5.0%), FGF signaling pathway (4.2%), gonadotropin-releasing hormone receptor pathway (4.2%), etc. There are four proteins in the gonadotropin-releasing hormone receptor pathway: vinculin (VCL), mitogen-activated protein kinase 3 (MAPK3), cell division control protein 42 homolog (Cdc42) and Ras-related C3 botulinum toxin substrate 1 (Rac1).