Compared with the female group, we identified 748 up-regulated proteins in group B. The PANTHER analysis showed that there were 11 protein classes involved in group B’s up-regulated proteins: nucleic acid-binding protein (29.2%), cytoskeletal protein (22.9%), protein-modifying enzyme (16.7%), chromatin/chromatin-binding or -regulatory protein (8.3%), transporter (6.3%), etc. These proteins belonged to 18 pathways, including Huntington’s disease (12.5%), the wnt signaling pathway (8.3%) and the hedgehog signaling pathway (8.3%). Here, DNM2 is linked to juvenile Huntington disease.