ZP3 and Huntington disease: Most proteins belonged to the integrin signaling pathway (15.6%), methylmalonyl pathway (6.7%), inflammation mediated by chemokine and cytokine signaling pathway (6.7%), glycolysis (4.4%), Huntington’s disease (4.4%), pyruvate metabolism (4.4%), CCKR signaling map (4.4%), de novo purine biosynthesis (4.4%), etc. The results showed that estradiol 17-beta-dehydrogenase 1, found in the androgen/estrogen/progesterone biosynthesis protein class, had high up-regulation in group C. Additionally, ZP3 was found in the reproductive processes (GO:0022414) of group C’s up-regulated proteins.