In prostate cancer cells miR-205 transcription is repressed, due to hypermethylation of the MIR-205 locus, which leads to a decrease in miR-205 expression and therefore to an increase in MED1 expression, since as mentioned earlier, miR-205 is able to target MED1 mRNA and reduces its expression [101]. Here, MED1 is linked to Familial prostate cancer.