WNK1 and pseudohypoaldosteronism type 2: In this regard, Zhang et al. reported two patients with hypokalemic salt-losing tubulopathies (SLTs) with inactivating mutations in the WNK1 kinase, although usually intronic heterozygous mutations on WNK1 are known to cause pseudohypoaldosteronism type II, the opposite phenotype of SLTs [25].