The analysis of the association between the polymorphisms we typed and the risk of dialysis in subjects suffering from hypercholesterolemia or diabetes do not allow us to identify associations with polymorphisms known to be associated with changes in lipid and carbohydrate metabolism as Klotho rs564481 [15,16], whereas MIF rs755622 genetic polymorphism might play a role in ESRD progression in subjects affected by these pathologies. Here, KL is linked to familial hypercholesterolemia.