TAC3 and asthma: These SNPs are located in genes whose functions are strongly related to inflammation activation mechanisms: C5, as already discussed, is a pro-inflammatory mediator in asthma conditions; the RAB14 gene regulates the endocytic transport of ADAM10, which influences the generation of Th2 immune responses [42]; TACR3 encodes for neurokinin B, involved in asthma pathophysiology by mediating neurogenic inflammation and lung functionality [43].