CCNE2 and Familial prostate cancer: Although we found only 6 DE genes on the KEGG Prostate Cancer Pathway (PRGFRA, PRGFRB, CCNE2, E2F2, EGFR and ZEB1), impact analysis identified that the down-regulation of all these genes led to EGFR inhibiting the activity of the MAPK signalling pathway but activating the PI3K-Akt and the p53 pathways, also related to senescence [113,114].