The SELP c.2177T>C variant was present in heterozygosity in the three osteoporotic male siblings (III1, III4, III5), as well as relatives II4, II5, II11 and III10, all of whom had mild osteopenia at the LS or a history of a low-trauma wrist fracture (in the case of II4). This evidence concerns the gene SELP and Osteopenia.