WNT1 and polycystic ovary syndrome: Additionally, in both human GCs and rat ovarian tissue PCOS models, a significant downregulation of miR-126-5p and miR-29a-5p, along with overexpression of its target, the klotho protein, and subsequent suppression of insulin growth factor 1 (IGF-1R) and Wnt family member 1 (Wnt1) were observed [38].