The possible reported mechanism of the EDN1 genes in hypertension is that the higher transcription of EDN1 increases the ET-1 production by the endothelial cells in the blood vessels, causing powerful constriction in the vascular smooth muscle cells and increasing peripheral resistance mediated via smooth vascular muscle subtype receptors (ETAR and ETBR) during pathological conditions [54]. The gene discussed is EDNRA; the disease is hypertensive disorder.