Adipose cells secrete approximately 50 exclusive cytokines, chemokines, and hormonal elements including IL-6, IL-8, IL-1β, tumor necrosis factor (TNF)-α, VEGF, CCL2, CCL5, and MMP9, which can also make a contribution to obesity and TME. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.