MMP2 and cancer: Their differentiation is stimulated by chemotactic factors secreted by cancer cells [186,187,188] to promote tumor progression such as proliferation induction, ECM remodeling, angiogenesis, and adaptive immune evasion [189,190,191], either by the release of EGF [192], or by the degradation of ECM proteins (MMP2 and MMP9) [37,108,109,110,140,141,142,143,144,193,194,195].