HIF1A and myocardial infarction: Examples of adaptations induced by hypoxia are the HIF-1α and VEGF-mediated angiogenesis in post-MI hearts to ensure a compensated O2 delivery in the infarcted tissue [57], and the downregulation of mitochondrial O2 consumption through the activity of the PDK1, which is the enzyme that limits the use of pyruvate at mitochondrial level [48].