In this study, Arakawa et al. provide evidence that GLP-1 agonism prevents the progression of atherosclerosis in ApoE−/− mice by reducing the expression of inflammatory mediators TNF-α (tumor necrosis factor α) and MCP-1 (important cytokines and chemokines with established atherogenic effect) in activated macrophages without major effects on metabolic parameters. This evidence concerns the gene GCG and atherosclerosis.