A total number of 346 apolipoprotein E knockout (ApoE−/−; ApoE−/− mice under normal circumstances spontaneously develop atherosclerosis) male mice from 17 weeks of age were divided into nine groups and were started to be, respectively, infused for 4 weeks with active or inactive forms of GLP-1 and GIP or saline (vehicle). This evidence concerns the gene APOE and atherosclerosis.