We have (1) described GIP and GLP-1 as expressed in many human tissues, (2) emphasized the relationship between GIP and GLP-1 and inflammation, (3) highlighted importance of GIP and GLP-1-dependent pathways in atherosclerosis and CAD, and (4) proved that GIP and GLP-1 could be used as markers of incidence, clinical course, and recurrence of CAD and related to the extent and severity of atherosclerosis and myocardial ischemia. The gene discussed is GIP; the disease is atherosclerosis.