Missense mutations in the TIA1 gene, responsible for Welander distal myopathy (WDM) [14] and amyotrophic lateral sclerosis (ALS), are characterized by delayed SG disassembly and accumulation of non-dynamic SGs that harbor cytotoxic TAR DNA-binding protein 43 (TARDBP, TDP43) [15]. This evidence concerns the gene TIA1 and amyotrophic lateral sclerosis.