Using the application of “Pathological Stage Plot” in GEPIA, we observed a significant differential expression of S100A7 between the pathological stages of various tumors, including breast invasive carcinoma (BRCA), DLBC, head and neck squamous cell carcinoma (HNSC), KIRC, SKCM, liver hepatocellular carcinoma (LIHC), READ, and UCEC (Figure 1D) but not other cancers, as displayed in Figure S6A–D. This evidence concerns the gene S100A7 and head and neck squamous cell carcinoma.