The pathway with the smallest p value among these pathways is the CVD–hematological disease pathway, which involved 15 proteins, namely MYOCD, PROS1, C2, SERPINA10, CRP, F5, C5, CFB, FGG, CFH, F12, PRDX2, PROZ, PPIA, and HABP2 (Figure 2). This evidence concerns the gene F12 and hematologic disorder.