PrEC treated with lycopene (up to 5 μmol/L) showed no expression of cyclin D1 in vitro. This regulatory subunit of kinases essential to the cancer cell cycle, resulting in reduced cancer cell cycle progression. High-performance liquid chromatography (HPLC) analysis, a thymidine incorporation assay, and flow cytometry were carried out to assess the impact of lycopene. Here, CCND1 is linked to cancer.