Further investigation illustrated that DNMT1/3A/3B, TDG, SMUG1, UNG, NEIL1, MDB3/4, ZBTB33, and UHRF1/2 were essentially upregulated in tumor samples, while TET2, MBD1, and MBD2 were downregulated in tumor samples (Figure 2E). This evidence concerns the gene MBD2 and neoplasm.