As a proof of this concept, mutation studies that induce Emery–Dreifuss muscular dystrophy (EDMD) conducted in C. elegans lamin (LMN-Y59C) coupled with the DamID identification of lamina associated chromatin showed that ablation of a protein that anchors H3K9- methylated chromatin, CEC-4, in the LMN-Y59C condition was able to reduce the disease phenotype and improve mobility of the worms [110]. Here, LMNB1 is linked to Emery-Dreifuss muscular dystrophy.