Within this context, the aim of this study is to evaluate the genomic, transcriptomic and proteomic alterations of 71 genes/proteins associated with APBs by using an integrated TCGA Pan-Cancer Atlas and multi-omics analyses in order to improve the understanding of the role of APBs in cancer, their correlation with ALT, and their application as potential molecular markers for the diagnosis and treatment of ALT+ cancers. The gene discussed is GPT; the disease is cancer.