NABP2 and ACD association with ALT is ambiguous [46,51]; ACD, also known as TPP1 is a main component of the shelterin complex, which is important to maintain telomere stability in normal cells; it has been reported that ACD repression promotes ALT in cancer cells [51]; Figure 4b showed ACD to be highly overexpressed in non-ALT tumors. The gene discussed is GPT; the disease is cancer.