GPT and cancer: mRNA up and downregulation is a measure to quantify the expression level of a certain gene and how it will correlate or affect protein expression as a post-transcriptional level, while CNV describes how the number of copies of a gene can be higher or lower from one individual to another, which can result in a loss or gain of functions [40]; in cancer, there is a close correlation between CNV and differential gene expression at a transcriptional level, therefore, the correlation of these alterations in the APBs-related genes may help to explain its function in the ALT pathway.