Moreover, a functional enrichment analysis showed that Fanconi anemia pathway proteins like FANCD2, which is correlated with APBs formation [47], was highly enriched in our protein set; one report suggests that FANCD2 depletion can lead to a high telomeric extension in APBs and positively regulate H2AX and TP53B1 proteins in ALT cells [53]; Figure 3b showed FANCD2 truncation, which is favorable for ALT activation. This evidence concerns the gene H2AX and Fanconi anemia.