Missense mutations and rare variants in CDH1 were identified in patients with non-syndromic CL/P [112,114,115,116,117], patients with hereditary diffuse gastric cancer and CL/P [118], as well as in one of the syndromic forms of CL/P (blepharocheilodontic syndrome, BCDS [111]). This evidence concerns the gene CDH1 and blepharocheilodontic syndrome.