To the best of our knowledge, ours is among the few studies, if not the first reported in the literature to assess three gene polymorphisms, i.e., TLR2 rs3804099, TLR2 rs3804100, and NLRP3 rs10754558, in children with H. pylori-induced gastritis, H. pylori-negative gastritis, and H. pylori-negative normal gastric mucosa in order to underline the early possible triggers of gastric carcinogenesis. This evidence concerns the gene NLRP3 and gastritis.