TLR2 and stomach disorder: Taking into account the association between both TLR2 rs380499 and NLRP3 rs10754558 gene polymorphisms and increased level of circulating neutrophils, also known as the key innate immune cells, involved in both local gastric and systemic inflammation, it is conceivable that host genetic factors are crucial for the development of H. pylori and non-H. pylori-induced gastropathies.