HAVCR1 and prostate carcinoma: Within PC-3 HAVcR-1EXPHAVcR-1, the staining increased within the cytoplasm and nucleus, as shown in Figure 2B. The conclusion here was that we successfully overexpressed or knocked down HAVcR-1 in an aggressive prostate cancer cell line (PC-3), with an increased expression of HAVcR-1 leading to cytoplasmic and nuclear location, compared to a diffuse location in unmodified cells.