This showed an increase in HAVcR1 gene expression in primary tumours; however, significance was not reached (p = 0.185), Figure 1D. The conclusion was that whilst HAVcR-1 expression was increased with prostate cancer progression, the shedding of the ectodomain was reduced, indicating that an unknown mechanism was involved in preventing shedding. This evidence concerns the gene HAVCR1 and prostate cancer.