Therefore, in this study, we sought to determine whether HAVcR-1 and/or the HAVcR-1 ectodomain would provide an effective biomarker for prostate cancer diagnosis and that through the dysregulation of epithelial cell adhesion, HAVcR-1 would contribute to the development and progression of the metastatic disease of prostate cancer. Here, HAVCR1 is linked to Familial prostate cancer.