Overall, these assays showed no change in resistance with PC3HAVcR-1EXP or PC3HAVcR-1KD, suggesting that HAVcR-1 has no effect on TJ integrity and is inconsistent with the hypothesis that the increased HAVcR-1 expression seen in prostate cancer is important for metastasis to occur via the decreased integrity of TJs. This evidence concerns the gene HAVCR1 and prostate carcinoma.