Altered expression of complement components is observed in the spinal cord during the progression of ALS, including upregulation of C1qB, C4, factor B, C3/C3b, C5, and especially C5aR, and a decrease in CD55, CD59, with most of these changes occurring in the vicinity of microglia [77]. The gene discussed is C3; the disease is amyotrophic lateral sclerosis.