Mouse embryonic fibroblasts (MEFs), mice tissues and cancer cell lines; p53-/- MEFs and cancer cells; pull-down assays in cancer cells; the p53 effect on G6PD dimerization in MEFs and cancer lines; ratios of G6PD and p53 in HCT116 p53+/+ cells are determined to depend on doxorubicin treatment (100:3 and 10:1 in the unstressed and doxorubicin-treated cells, correspondingly). The gene discussed is TP53; the disease is cancer.