cIAP1 and cIAP2-encoding genes (named BIRC2 and BIRC3) are very closely located on chromosome locus 11q22.2, a region found amplified (11q21 amplicon) in human medulloblastoma, hepatic, breast, pancreatic, cervical, lung, oral squamous cell and esophageal carcinoma [55]. This evidence concerns the gene BIRC3 and carcinoma of esophagus.