Some PTPs, such as PTPN1, PTPN2, PTPN9, PTPN11, PTPRS, and DUSP9, have been shown to attenuate insulin signaling and trigger type 2 diabetes, indicating that PTPs are promising drug targets for the treatment or prevention of type 2 diabetes [5,6]. This evidence concerns the gene INS and type 2 diabetes mellitus.