To shed light on the role of TNTs with respect to DC exposure to complement-opsonized HIV, we treated DCs alone or in co-cultures with CD4+ T cells with cytarabine (AraC), a pyrimidine nucleoside analog recently demonstrated to reduce TNT formation by interfering with NFκB activation in acute myeloid leukemia (AML) [53] and in HTLV-1 cells [62]. Here, CD4 is linked to acute myeloid leukemia.