Similar results were obtained when HIV-C-infected DC/CD4+ T-cell co-cultures were treated with anaphylatoxin receptor antagonists, with only C5aRi significantly decreasing TNT formation (Figure 4a), productive infection (Figure 4b) and complement production (Figure 4c), indicating a block in trans infection from DCs to CD4+ T cells via TNTs. The gene discussed is CD4; the disease is infection.