In 2019, Gao and colleagues [160] exploited the third extracellular region (S5/S6) of Nav1.5 to prevent the progression of three types of cancer; breast cancer (breast adenocarcinoma cells, MDA-MB-231), ovarian cancer (ovarian adenocarcinoma cells, Caov-3), and cervical squamous cancer (SiHa cells). This evidence concerns the gene SCN5A and cancer.