Wnt5a from the osteoblastic niche has also been shown to induce prostate cancer cell dormancy in bone in the intra-tibial PC-3 xenograft model, involving the inhibition of Wnt/β-catenin signaling through the potentiation of ROR2-SIAH2 signaling [142]. The gene discussed is WNT5A; the disease is Familial prostate cancer.