The proto-oncogene β-catenin is a key mediator of canonical Wnt signaling that regulates the transcription of Wnt target genes and interacts with additional signaling pathways (e.g., AR, MAPK, and PI3K cascades) and E-cadherin to coordinate cellular processes such as cell adhesion, proliferation, survival, and stemness during development, regeneration and tumor growth [19,50,70]. Here, AR is linked to neoplasm.