For instance, large tumor suppressor kinase 2 (LATS2) has been shown to inhibit β-catenin:BCL9 mediated transcription independently from its role in the Hippo pathway where it phosphorylates YAP, and the microtubule inhibitor nocodazole can induce LATS2 to suppress β-catenin:BCL9 mediated transcription in human colorectal cancer cell lines [94]. The gene discussed is BCL9; the disease is colorectal cancer.