RSPO3 siRNA-mediated knockdown in human prostate cancer cell lines increases invasive capacity in vitro, supporting a tumor-suppressive role for RSPO3 in prostate cancer [166], whereas tissue regeneration upon androgen replacement post-androgen deprivation involves the upregulation of RSPO3 by mesenchymal cells [168]. The gene discussed is RSPO3; the disease is prostate carcinoma.