WNT5A and Familial prostate cancer: For instance, osteoblasts derived from neonatal rats can induce quiescence in prostate cancer cells in vitro, and transcriptomic analysis of the osteoblasts detected high expression levels of Wnt ligands (Wnt5a, Wnt5b, Wnt11, and Wnt16), suggesting non-canonical Wnt signaling may mediate prostate cancer cell dormancy in bone [142].