Increased transcription of FZD3/5/7/8 has also been linked to TMPRSS2-ERG (Transmembrane serine protease 2–ETS Transcription Factor ERG fusion protein) gene-fusion positive prostate tumors, and the ERG-regulator SOX9 has been shown to positively correlate with Wnt activity and the upregulation of Wnt pathway components, including FZD7 mRNA in advanced prostate cancer models and primary prostate cancer clinical specimens [100,101,102,103,104]. This evidence concerns the gene TMPRSS2 and Familial prostate cancer.