Conditioned media from bone marrow-derived mesenchymal stem cells MC3T3-E1 and hFOB1.19 rich in Wnt5a can also induce prostate cancer cell dormancy, indicating Wnt5a is secreted from a plethora of cell types within the bone microenvironment to promote dormancy of disseminated tumor cells [142]. This evidence concerns the gene WNT5A and Familial prostate cancer.