Little research has focused on LGR6 in prostate cancer, although a previous study has shown LGR6 mRNA is not expressed in primary luminal, basal, or stromal cells that were isolated by fluorescence-activated cell sorting (FACS) from adult mouse prostate tissue [116] and LGR6 upregulation in ovarian cancer predict for poor prognosis [112]. This evidence concerns the gene LGR6 and Familial prostate cancer.