High levels of LGR4 mRNA in prostate cancer also positively correlate with shorter recurrence free-survival in the clinic, and LGR4 loss in the TRAMP mouse model of neuroendocrine prostate cancer delays the onset of prostate intraepithelial neoplasia (PIN) in vivo, associated with increased survival and reduced lung metastasis [114]. Here, LGR4 is linked to prostate cancer.