Several conditions could lead to ATN, but two significant groups were usually described: (1) ischemia-related, as observed during marked hypotension/shock conditions, such as acute pancreatitis and trauma, and (2) nephrotoxic-related agents (e.g., drugs (gentamycin, cisplatin, methotrexate), hemoglobin, myoglobin). The gene discussed is MB; the disease is acute pancreatitis.