A major limitation of this type of approach is that plasma MMP or TIMP concentration fluctuates in sepsis according to the stage of the disease, and each MMP might have different timing in appearance, some being immediately released by activated neutrophils (e.g., MMP-8 and MMP-9) [11] while others are expressed and released by inflamed tissues over a different time period [12]. This evidence concerns the gene MMP8 and Sepsis.