ACE and type 1 diabetes mellitus: On the other hand, an 8-weeks study on 87 murine models with type 1 diabetes rather suggested that glycemic control was more important than pravastatin to attenuate the progression of DC, expressed as the cardiac expression of collagen I/III, matrix metalloproteinase (MMP)-2, MMP-9, and angiotensin-converting enzyme (ACE) [114].