The combination of [TIMP-2] × [IGFBP7] at a cutoff of 0.2 (ng/mL)2/1000 were the second best AKI predictors, and the performance of these biomarkers during the whole hospitalization was similar to that of day 7 (AUC= 0.682 vs. AUC= 0.671; p = 0.632). This evidence concerns the gene IGFBP7 and acute kidney injury.