Further, biodegradable poly(β-amino ester) nanoparticle-based delivery of a plasmid encoding vascular endothelial growth factor (VEGF) neutralizing protein, p3sF1t1Fc, significantly suppressed vascular leakage and neovascularization in a mouse model of wet age-related macular degeneration (AMD) [36]. Here, VEGFA is linked to wet macular degeneration.