More recently, exome and genome sequencing studies have identified novel PAH risk genes outside of the BMPR2 pathway, including three channel genes: ATP-binding cassette subfamily member 8 (ABCC8), ATPase 13A3 (ATP13A3), and potassium two-pore domain channel (KCNK3). The gene discussed is ABCC8; the disease is pulmonary arterial hypertension.