Human β-defensins HBD-1 and HBD-3 also exhibit modulatory activity against actin regulators such as Rho family proteins, vascular endothelial growth factor (VEGF) and metastasis-associated 1 family member 2 (MTA2), resulting in anti-migratory effects against oral squamous cell carcinoma [14,15], head and neck [16] and colon cancer cells [17]. This evidence concerns the gene VEGFA and oral cavity squamous cell carcinoma.