PI(4,5)P2-producing enzymes phosphatidylinositol 5-phosphate 4-kinase (PIP4K) and phosphatidylinositol 4-phosphate 5-kinase type 1 alpha (PIP5KIα) are also overexpressed in various cancers, such as triple-negative breast cancers, HER2-positive breast cancer, advanced prostate cancer and luminal ER+ cancer [42,43,44,45,46,47,48]. This evidence concerns the gene ERBB2 and cancer.