Although the symptomology of behavioral changes and memory loss was not atypical for what the scientific society had previously observed, his histological experiments on the brain of the then deceased patient were unique and provided the basis of what we now know to be tau-associated neurofibrillary tangles (NFTs) and β-amyloid (Aβ) plaques in what is known as Alzheimer’s Disease (AD) [1]. Here, MAPT is linked to Alzheimer disease.