NOTCH1 and Alzheimer disease: In descending order, the top 10 hub nodes (highest degree centrality) were AKT1, UBC, EP300, CREBBP, MAPK1, FYN, CTNNB1, PIK3CA, GRB2 and STAT3, whereas the top bottleneck nodes (highest betweenness centrality) were UBC, AKT1, CTNNB1, FYN, EP300, MAPK1, CREBBP, PRKACA, GRB2 and NOTCH1. Interestingly, all these genes were part of MADgs, except for UBC (Ubiquitin-C) which appears to be quite significant for our biological network and it is understudied for its role in AD in the current literature.