HLA-G and systemic sclerosis: Moreover, there are data supporting the correlating levels of total sHLA-G in plasma with elevated TGF-β levels in systemic sclerosis, TGF-β also being one major factor upregulating HLA-G expression in cancers, and subsequently influencing immune cells mainly Treg cells and, on the other hand, participating in cancer immune escape and immune checkpoint resistance [110,111].