TWIST1 and breast neoplasm: Furthermore, it has been reported that BthTx-II inhibits the migration, adhesion, and invasion of TBNC cells in the integrin-mediated cell cycle and interferes with the epithelial–mesenchymal transition process of highly metastatic breast tumor cells (MDA-MB-231 cells) by reducing the expression of important genes and proteins related to the metastatic process, such as CK-5, Vimentin, CTNNB1, and TWIST1, and by increasing E-cadherin (CDH-1) [17].