Previous research reported that baicalin specifically binds to the active site of RANKL and inhibits osteoporosis by regulation of the RANK/RANKL/OPG pathway in vitro and in vivo through bone modeling transcription factors, such as nuclear factor κB2 (nfκb2), TNF receptor-associated factor 6 (traf6), forkhead box O1 a2 (foxo1a2), mitogen-activated protein kinase 8b (mapk8b), TNF superfamily member 13b (tnfsl3b), and bone tissue mineralization, growth, and development in the dexamethasone (DEX)-induced osteoporosis zebrafish larvae model [12]. This evidence concerns the gene TNFSF13B and osteoporosis.