Also, it was demonstrated that B. longum accompanied with FOS decreases C- reactive protein (CRP), TNF-α, serum Aspartate transaminase (AST) levels, serum endotoxin, steatosis, HOMA-IR, and the nonalcoholic steatohepatitis activity index significantly [63]. The gene discussed is CRP; the disease is metabolic dysfunction-associated steatohepatitis.