In the MPTP monkey model of PD, the combination of BP 897 (a partial agonist possessing 70-fold selectivity for D3R over D2R [190]) with l-DOPA reduced LID by 66%; however, it did not exhibit a functional effect of the motor recovery obtained with l-DOPA, presumably due to its lack of selectivity in vivo. Here, DRD2 is linked to Parkinson disease.