PPARA and diabetes mellitus: Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT; NCT03071692), an ongoing trial of pemafibrate (a selective PPAR α modulator that significantly lowers triglyceride) in patients with type 2 diabetes mellitus, mild-to-moderate hypertriglyceridemia, and low HDL-cholesterol might further shed light on the mechanism of triglyceride-lowering agents on ASCVD [46].